TedTest

From the Ted Talk by Karen D. Davis: How does your brain respond to pain?

Unscramble the Blue Letters

Let's say that it would take you ten minutes to solve this puzlze. How long would it take if you received constant electric schkos to your hands? Longer, right? Because the pain would distract you from the task. Well, maybe not; it depends on how you handle pain. Some people are distracted by pain. It takes them lnegor to complete a task, and they do it less well. Other people use tkass to distract themselves from pain, and those people actually do the task faster and better when they're in pain than when they're not. Some polepe can just send their mind wandering to distract themselves from pain. How can different people be subjected to the exact same painful sumltuis and yet experience the pain so differently? And why does this mtetar? First of all, what is pain? Pain is an unpleasant sensory and eonmaotil experience, associated with atucal or potential tissue damage. Pain is something we eceixprnee, so it's best measured by what you say it is. Pain has an intensity; you can describe it on a scale from zero, no pain, to ten, the most pain iganlmbiae. But pain also has a caachetrr, like sharp, dull, burning, or aching. What exactly creates these ppenrcteois of pain? Well, when you get hurt, special tissue damage-sensing nreve cells, called nociceptors, fire and send signals to the spinal cord and then up to the brain. psecsnirog work gets done by cells called neurons and glia. This is your Grey matter. And brain superhighways carry information as eacecitrll iseplmus from one area to another. This is your white matter. The superhighway that carries pain imiofrotann from the spinal cord to the brain is our ssienng pathway that ends in the cortex, a part of the brain that decides what to do with the pain signal. Another system of interconnected brain cells called the salience network decides what to pay attention to. Since pain can have serious consequences, the pain signal immediately activates the salience network. Now, you're paying attention. The brain also rposneds to the pain and has to cope with these pain signals. So, motor pathways are activated to take your hand off a hot stove, for example. But modulation networks are also activated that deliver endorphins and enkephalins, chemicals released when you're in pain or during extreme exercise, creating the runner's high. These chemical systems help regulate and reduce pain. All these networks and pathways work together to create your pain experience, to prevent further tissue damage, and help you to cope with pain. This system is similar for everyone, but the sensitivity and efficacy of these brain circuits determines how much you feel and cope with pain. This is why some people have greater pain than others and why some develop chronic pain that does not rnpesod to treatment, while others respond well. Variability in pain siiteiitvness is not so different than all kinds of variability in responses to other stimuli. Like how some people love roller coasters, but other people suffer from terrible motion sickness. Why does it matter that there is vlriaiabtiy in our pain brain circuits? Well, there are many treatments for pain, targeting different seymsts. For mild pain, non-prescription medications can act on cells where the pain signals satrt. Other stronger pain medicines and anesthetics work by reducing the activity in pain-sensing circuits or boosting our cipnog setsym, or endorphins. Some people can cope with pain using methods that ilnovve distraction, rltaoxiean, meditation, yoga, or strategies that can be taught, like cognitive bohreaiavl terahpy. For some people who suffer from severe chronic pain, that is pain that doesn't go away months after their injury should have healed, none of the rlugaer treatments work. Traditionally, medical science has been about testing treatments on large gorups to determine what would help a mjtioary of patients. But this has usually left out some who didn't benfeit from the treatment or experienced side effects. Now, new taetmetrns that directly stimulate or block certain pain-sensing atteonitn or modulation networks are being developed, along with ways to tlaoir them to individual pniettas, using tools like minetgac resonance imaging to map brain pathways. fiiugrng out how your brain responds to pain is the key to finding the best tanmetret for you. That's true pieozrlenasd medicine.

Open Cloze

Let's say that it would take you ten minutes to solve this ______. How long would it take if you received constant electric ______ to your hands? Longer, right? Because the pain would distract you from the task. Well, maybe not; it depends on how you handle pain. Some people are distracted by pain. It takes them ______ to complete a task, and they do it less well. Other people use _____ to distract themselves from pain, and those people actually do the task faster and better when they're in pain than when they're not. Some ______ can just send their mind wandering to distract themselves from pain. How can different people be subjected to the exact same painful ________ and yet experience the pain so differently? And why does this ______? First of all, what is pain? Pain is an unpleasant sensory and _________ experience, associated with ______ or potential tissue damage. Pain is something we __________, so it's best measured by what you say it is. Pain has an intensity; you can describe it on a scale from zero, no pain, to ten, the most pain __________. But pain also has a _________, like sharp, dull, burning, or aching. What exactly creates these ___________ of pain? Well, when you get hurt, special tissue damage-sensing _____ cells, called nociceptors, fire and send signals to the spinal cord and then up to the brain. __________ work gets done by cells called neurons and glia. This is your Grey matter. And brain superhighways carry information as __________ ________ from one area to another. This is your white matter. The superhighway that carries pain ___________ from the spinal cord to the brain is our _______ pathway that ends in the cortex, a part of the brain that decides what to do with the pain signal. Another system of interconnected brain cells called the salience network decides what to pay attention to. Since pain can have serious consequences, the pain signal immediately activates the salience network. Now, you're paying attention. The brain also ________ to the pain and has to cope with these pain signals. So, motor pathways are activated to take your hand off a hot stove, for example. But modulation networks are also activated that deliver endorphins and enkephalins, chemicals released when you're in pain or during extreme exercise, creating the runner's high. These chemical systems help regulate and reduce pain. All these networks and pathways work together to create your pain experience, to prevent further tissue damage, and help you to cope with pain. This system is similar for everyone, but the sensitivity and efficacy of these brain circuits determines how much you feel and cope with pain. This is why some people have greater pain than others and why some develop chronic pain that does not _______ to treatment, while others respond well. Variability in pain _____________ is not so different than all kinds of variability in responses to other stimuli. Like how some people love roller coasters, but other people suffer from terrible motion sickness. Why does it matter that there is ___________ in our pain brain circuits? Well, there are many treatments for pain, targeting different _______. For mild pain, non-prescription medications can act on cells where the pain signals _____. Other stronger pain medicines and anesthetics work by reducing the activity in pain-sensing circuits or boosting our ______ ______, or endorphins. Some people can cope with pain using methods that _______ distraction, __________, meditation, yoga, or strategies that can be taught, like cognitive __________ _______. For some people who suffer from severe chronic pain, that is pain that doesn't go away months after their injury should have healed, none of the _______ treatments work. Traditionally, medical science has been about testing treatments on large ______ to determine what would help a ________ of patients. But this has usually left out some who didn't _______ from the treatment or experienced side effects. Now, new __________ that directly stimulate or block certain pain-sensing _________ or modulation networks are being developed, along with ways to ______ them to individual ________, using tools like ________ resonance imaging to map brain pathways. ________ out how your brain responds to pain is the key to finding the best _________ for you. That's true ____________ medicine.

Solution

impulses
figuring
regular
responds
system
variability
people
majority
processing
relaxation
start
systems
perceptions
longer
character
patients
therapy
puzzle
imaginable
involve
shocks
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treatments
nerve
coping
sensitivities
stimulus
tailor
magnetic
emotional
personalized
treatment
sensing
information
experience
matter
actual
behavioral
electrical
respond

Original Text

Let's say that it would take you ten minutes to solve this puzzle. How long would it take if you received constant electric shocks to your hands? Longer, right? Because the pain would distract you from the task. Well, maybe not; it depends on how you handle pain. Some people are distracted by pain. It takes them longer to complete a task, and they do it less well. Other people use tasks to distract themselves from pain, and those people actually do the task faster and better when they're in pain than when they're not. Some people can just send their mind wandering to distract themselves from pain. How can different people be subjected to the exact same painful stimulus and yet experience the pain so differently? And why does this matter? First of all, what is pain? Pain is an unpleasant sensory and emotional experience, associated with actual or potential tissue damage. Pain is something we experience, so it's best measured by what you say it is. Pain has an intensity; you can describe it on a scale from zero, no pain, to ten, the most pain imaginable. But pain also has a character, like sharp, dull, burning, or aching. What exactly creates these perceptions of pain? Well, when you get hurt, special tissue damage-sensing nerve cells, called nociceptors, fire and send signals to the spinal cord and then up to the brain. Processing work gets done by cells called neurons and glia. This is your Grey matter. And brain superhighways carry information as electrical impulses from one area to another. This is your white matter. The superhighway that carries pain information from the spinal cord to the brain is our sensing pathway that ends in the cortex, a part of the brain that decides what to do with the pain signal. Another system of interconnected brain cells called the salience network decides what to pay attention to. Since pain can have serious consequences, the pain signal immediately activates the salience network. Now, you're paying attention. The brain also responds to the pain and has to cope with these pain signals. So, motor pathways are activated to take your hand off a hot stove, for example. But modulation networks are also activated that deliver endorphins and enkephalins, chemicals released when you're in pain or during extreme exercise, creating the runner's high. These chemical systems help regulate and reduce pain. All these networks and pathways work together to create your pain experience, to prevent further tissue damage, and help you to cope with pain. This system is similar for everyone, but the sensitivity and efficacy of these brain circuits determines how much you feel and cope with pain. This is why some people have greater pain than others and why some develop chronic pain that does not respond to treatment, while others respond well. Variability in pain sensitivities is not so different than all kinds of variability in responses to other stimuli. Like how some people love roller coasters, but other people suffer from terrible motion sickness. Why does it matter that there is variability in our pain brain circuits? Well, there are many treatments for pain, targeting different systems. For mild pain, non-prescription medications can act on cells where the pain signals start. Other stronger pain medicines and anesthetics work by reducing the activity in pain-sensing circuits or boosting our coping system, or endorphins. Some people can cope with pain using methods that involve distraction, relaxation, meditation, yoga, or strategies that can be taught, like cognitive behavioral therapy. For some people who suffer from severe chronic pain, that is pain that doesn't go away months after their injury should have healed, none of the regular treatments work. Traditionally, medical science has been about testing treatments on large groups to determine what would help a majority of patients. But this has usually left out some who didn't benefit from the treatment or experienced side effects. Now, new treatments that directly stimulate or block certain pain-sensing attention or modulation networks are being developed, along with ways to tailor them to individual patients, using tools like magnetic resonance imaging to map brain pathways. Figuring out how your brain responds to pain is the key to finding the best treatment for you. That's true personalized medicine.

Frequently Occurring Word Combinations

ngrams of length 2

collocation	frequency
spinal cord	2
cells called	2
pain signal	2
salience network	2
pain signals	2
modulation networks	2

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